P907 NOD2 mutations are associated with the development of inflammatory and progressive digestive tract damage in Crohn’s disease

Abstract Background Single-nucleotide polymorphisms (SNP) of the Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) gene are associated with higher risk for Crohn′s disease (CD). It has also been reported that they more likely to associate specific phenotypes such as stricturing or perianal and need resection surgery. The aim our study was investigate if these NOD2 variants cumulative bowel damage in Crohn’s disease. Methods We performed genotyping a cohort 150 patients CD from tertiary care center Germany. SNP 8 (R702W, rs2066844), 12 (G908R, rs2066845), 13 (1007fs, rs2066847) were screened for. Lémann-Index (LI) calculated estimate digestive tract each patient. Additionally, we collected following data: age at diagnosis, location behaviour using Montréal classification, duration. Results Fifty carried least one three SNPs. In univariate analysis, LI risk-SNP not significantly different without (NOD2 WT), 13.62 ± 15.10 vs. 11.57 13.08, p=0.196. Also, after stratification single polymorphisms, SNP. However, non-stricturing, non-penetrating behavior (Montréal classification B1), 2.61 2.80 0.85 1.82, p=0.007. Importantly, presence SNP13 strong correlation between duration found, rp = 0.69. contrast, only weak detectable WT, rs 0.30 (figure 1). an early onset than who first diagnosed age. Conclusion high during behaviour. line this, observed diagnosis young polymorphism SNP13. Finally, data suggest particularly predisposes progressive accumulation over course.